Skip Navigation LinksHome > April 2012 - Volume 54 - Issue 4 > Association Between Proinflammatory Responses of Respirable...
Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e31824525ab
Original Articles

Association Between Proinflammatory Responses of Respirable Silica Dust and Adverse Health Effects Among Dust-Exposed Workers

Zhou, Ting MD; Rong, Yi MD; Liu, Yuewei MD, PhD; Zhou, Yun MD; Guo, Jiali MD; Cheng, Wenjuan MD, MS; Wang, Haijiao MD, PhD; Chen, Weihong MD, PhD

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Objective: To evaluate proinflammatory responses induced by respirable silica dust samples and to analyze the role of those responses in explaining adverse health effects among dust-exposed workers in pottery factoryies and tungsten and tin mines.

Methods: Proinflammatory cytokines of cells were determined after being treated with silica dust samples. Adverse health effects of workers were calculated on the basis of a cohort study.

Results: Incidence and mortality of silicosis among tungsten miners were higher than those in other workers. The incidence of interleukin-1β levels was highestin tungsten mines, which was consistent with the incidence of silicosis in tungsten miners. The higher levels of TNF-α and interleukin-6 released from macrophages might be helpful in explaining increased mortalities from lung cancer among tin miners.

Conclusions: Interleukin-1β could be asensitive biomarker in predicting fibrogenic potential of silica dust and the risk of silicosis among dust-exposed workers.

©2012The American College of Occupational and Environmental Medicine


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