Objective: To evaluate the correlation between chromate exposure and binucleated cells with micronuclei (BNMN) frequencies in chromate production workers and explore the ideal biomarker to detect early DNA damage.
Methods: There are 79 workers and 112 peasants in this study. Chromium concentrations in the air (CrA), blood (CrB), and urine (CrU) were detected. BNMN frequencies were also counted.
Results: The CrA, CrB, CrU, and BNMN frequencies of the exposure group were higher than those of the control group; BNMN frequencies were positively correlated with CrB and CrU; natural logarithm (Ln) BNMN was regressed on CrB, CrU, and CrA by linear models.
Conclusions: The increases in CrB, CrU, and BNMN frequencies caused by lower CrA level suggest BNMN frequencies could be used to detect early DNA damage in the chromate production health surveillance.
From the School of Public Health (Drs Xiaohua, Yanshuang, and Guang and Mss Lei and Wenjun), Department of Occupational and Environmental Health Sciences, Peking University, Beijing, China; Baotou Medical College (Ms Li), Baotou City; Hospital of Inner Mongolia North Heavy Industries Group (Ms Li), the Inner Monggol Autonomous Region, China; and Jinan Municipal Center for Disease Control & Prevention (Ms Yanhui and Ji), Shandong Province, China.
Address Correspondence to: Jia Guang, MD, PhD, Department of Occupational and Environmental Health, School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, 100191, Beijing, China (firstname.lastname@example.org).