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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e31823d86b4
Original Articles

Evaluation of the Correlation Between Genetic Damage and Occupational Chromate Exposure Through BNMN Frequencies

Xiaohua, Liu MD; Yanshuang, Song MD; Li, Wang MM; Yuhui, Li BM; Ji, Zhang MM; Yanhui, Ma MM; Yun, Wang MD; Wenjun, Ma MM; Lei, Yan MM; Guang, Jia MD

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Abstract

Objective: To evaluate the correlation between chromate exposure and binucleated cells with micronuclei (BNMN) frequencies in chromate production workers and explore the ideal biomarker to detect early DNA damage.

Methods: There are 79 workers and 112 peasants in this study. Chromium concentrations in the air (CrA), blood (CrB), and urine (CrU) were detected. BNMN frequencies were also counted.

Results: The CrA, CrB, CrU, and BNMN frequencies of the exposure group were higher than those of the control group; BNMN frequencies were positively correlated with CrB and CrU; natural logarithm (Ln) BNMN was regressed on CrB, CrU, and CrA by linear models.

Conclusions: The increases in CrB, CrU, and BNMN frequencies caused by lower CrA level suggest BNMN frequencies could be used to detect early DNA damage in the chromate production health surveillance.

©2012The American College of Occupational and Environmental Medicine

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