Objective: To evaluate the correlation between chromate exposure and binucleated cells with micronuclei (BNMN) frequencies in chromate production workers and explore the ideal biomarker to detect early DNA damage.
Methods: There are 79 workers and 112 peasants in this study. Chromium concentrations in the air (CrA), blood (CrB), and urine (CrU) were detected. BNMN frequencies were also counted.
Results: The CrA, CrB, CrU, and BNMN frequencies of the exposure group were higher than those of the control group; BNMN frequencies were positively correlated with CrB and CrU; natural logarithm (Ln) BNMN was regressed on CrB, CrU, and CrA by linear models.
Conclusions: The increases in CrB, CrU, and BNMN frequencies caused by lower CrA level suggest BNMN frequencies could be used to detect early DNA damage in the chromate production health surveillance.