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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e31821ad724
Epidemiologic Research: Original Article

Identification of Systemic Markers from A Pulmonary Carbon Nanotube Exposure

Erdely, Aaron PhD; Liston, Angie BS; Salmen-Muniz, Rebecca AAS; Hulderman, Tracy BS, MT; Young, Shih-Houng PhD; Zeidler-Erdely, Patti C. PhD; Castranova, Vincent PhD; Simeonova, Petia P. MD, PhD

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Abstract

Objective: Interest exists for early monitoring of worker exposure to engineered nanomaterials. Here, we highlight quantitative systemic markers of early effects after carbon nanotube (CNT) exposure.

Methods: Mice were exposed by pharyngeal aspiration to 40-μg CNT and harvested 24 hours, 7 days, and 28 days postexposure for measurements of whole blood, lung and extrapulmonary tissue gene expression, blood and bronchoalveolar lavage (BAL) differentials, and serum protein profiling.

Results: Early effects included increased inflammatory blood gene expression and serum cytokines followed by an acute phase response (eg, CRP, SAA-1, SAP). Beyond 24 hours, there was a consistent increase in blood and BAL eosinophils. At 28 day, serum acute phase proteins with immune function including complement C3, apolipoproteins A-I and A-II, and α2-macroglobulin were increased.

Conclusions: Carbon nanotube exposure resulted in measurable systemic markers but lacked specificity to distinguish from other pulmonary exposures.

©2011The American College of Occupational and Environmental Medicine

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