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Hematological, Biochemical Effects, and Self-reported Symptoms in Pesticide Retailers

Rojas-García, Aurora Elizabeth PhD; Medina-Díaz, Irma Martha PhD; Robledo-Marenco, María de Lourdes PhD; Barrón-Vivanco, Briscia Socorro MD; Girón-Pérez, Manuel Iván PhD; Velázquez-Fernández, Jesús Bernardino PhD; González-Arias, Cyndia Azucena QFB; Albores-Medina, Arnulfo PhD; Quintanilla-Vega, Betzabet PhD; Ostrosky-Wegman, Patricia PhD; Rojas-García, María Consuelo MD; Pérez-Herrera, Norma Elena PhD; López-Flores, Juan Fernando MD

Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e318215fbf2
Original Articles
Abstract

Objective: This study evaluates the effects of exposure to pesticides on the health of pesticide retailers.

Methods: The study population comprised 83-male pesticide retailers and 98 controls. Serum butyrylcholinesterase levels and complete blood analysis were performed in a certified laboratory and each subject completed a structured questionnaire.

Results: Butyrylcholinesterase activity and hematological parameters such as hemoglobin and hematocrit were significantly lower in pesticide retailers than in control subjects. In contrast, platelet count as well as hepatic parameters such as glutamic-pyruvate transaminase and gamma-glutamyl transpeptidase activities was higher in pesticide retailers. Furthermore, pesticide retailers experienced burning sensations in the skin more frequently than controls.

Conclusions: These preliminary results suggest the importance of evaluating further toxicological biomarkers in these populations.

Author Information

From the Laboratorio de Contaminación y Toxicología Ambiental, Secretaría de Investigación y Posgrado (Drs AE Rojas-García, Medina-Díaz, Robledo-Marenco, Barrón-Vivanco, Giróon-Pérez, Velázquez-Fernández, and MC Rojas-García and Ms González-Arias), Universidad Autónoma de Nayarit, Tepic, Mexico; Departamento de Toxicología (Drs Barrón-Vivanco, Albores-Medina, and, Quintanilla-Vega), Centro de Investigación y de Estudios Avanzados del IPN, Mexico; Instituto de Investigaciones Biomédicas (Dr Ostrosky-Wegman), UNAM, Ciudad Universitaria, Mexico; Subdirección de Enseñanza Estatal (Dr MC Rojas-García), Servicios de Salud de Nayarit, Mexico; Laboratorio de Enfermedades Crónicas y Degenerativas (Dr Pérez-Herrera), Unidad Interinstitucional de Investigación Clínica y Epidemiológica, Facultad de Medicina, Universidad Autónoma de Yucatán, Mérida, Mexico; and Departamento de Enseñanza e-Investigación, Hospital Civil “Dr. Antonio González Guevara” (Dr López-Flores), Secretaría de Salud de Nayarit, Mexico.

Address correspondence to: Aurora Elizabeth Rojas-García, PhD, Laboratorio de Contaminación y Toxicología Ambiental. Secretaría de Investigación y Posgrado. Universidad Autónoma de Nayarit. Tepic, Nayarit, México 63155 (erojas@uan.edu.mx).

©2011The American College of Occupational and Environmental Medicine