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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e31820c2bff
Original Articles

Respirable Crystalline Silica Exposure–Response Evaluation of Silicosis Morbidity and Lung Cancer Mortality in the German Porcelain Industry Cohort

Mundt, Kenneth A PhD; Birk, Thomas Dipl rer soc; Parsons, William MS; Borsch-Galetke, Elisabeth PhD, MD; Siegmund, Klaus MD; Heavner, Karyn PhD; Guldner, Karlheinz PhD

Supplemental Author Material
Erratum

Erratum

Kenneth A. Mundt, PhD, Thomas Birk, Dipl rer soc, and Lori Crawford, MS

While conducting more advanced analyses of the German Porcelain Industry Cohort data the authors uncovered an error in the coding of person-time for the non-silicosis cases. Specifically, in the original version, person-time was accrued until end of follow-up instead of the date of the last available negative radiograph, as stated in the text. The more advanced data analyses included treatment of age as a time-dependent parameter (vs. age at end of follow-up in the original report). Results due to the treatment of age were negligibly different. A corrected version of Table 3 is provided, as well as a new set of supplemental tables (see Supplemental Digital Content Table A at http://links.lww.com/JOM/A47, Table B at http://links.lww.com/JOM/A48, and Table C at http://links.lww.com/JOM/A49), both of which include age as a time-dependent variable.

Journal of Occupational and Environmental Medicine. 54(10):1309, October 2012.

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Abstract

Objective: To quantify silicosis and lung cancer risks among porcelain workers occupationally exposed to respirable crystalline silica.

Methods: We reread historical radiographs to identify silicosis and estimated exposure on the basis of detailed work history and about 8000 industrial hygiene measurements. Cox proportional hazards models estimated risks by cumulative and average exposure.

Results: Adjusted silicosis hazards ratios were 5.3 (95% confidence interval [CI], 1.6 to 17.3); 7.3 (95% CI, 2.6 to 20.8); and 6.8 (95% CI, 3.0 to 15.3) for cumulative exposures >4 to 5; >5 to 6; and >6 mg/m3-years, and 3.3 (95% CI, 0.8 to 14.7), 13.6 (95% CI, 4.2 to 44.4) and 23.2 (95% CI, 8.2 to 65.8) for average exposures >0.1 to 0.15; >0.15 to 0.2 and >0.2 mg/m3, respectively. Exposure was not associated with any cause of death including lung cancer.

Conclusions: Respirable crystalline silica exposure more than 4 mg/m3-years (cumulative) or more than 0.15 mg/m3 (average) were strongly associated with silicosis, but unrelated to lung cancer risks.

©2011The American College of Occupational and Environmental Medicine

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