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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e3181e48ec8
Original Articles

Association Between IL-1A Single Nucleotide Polymorphisms and Chronic Beryllium Disease and Beryllium Sensitization.

McCanlies, Erin C. PhD; Yucesoy, Berran PhD; Mnatsakanova, Anna MS; Slaven, James E. MS; Andrew, Michael PhD; Frye, Bonnie L. BS; Schuler, Christine R. PhD; Kreiss, Kathleen MD; Weston, Ainsley PhD

Continued Medical Education
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Abstract

Objective: To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS).

Methods: Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5′ nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1Glu69 in additive, dominant, and recessive inheritance models.

Results: IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized.

Conclusions: These results indicate that genetic variations in the IL-1A gene may play a role in the development of CBD but not BeS.

©2010The American College of Occupational and Environmental Medicine

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