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Association Between Fine Particulate Matter and Oxidative DNA Damage May Be Modified in Individuals With Hypertension

Kim, Jee Young ScD; Prouty, Lacey A. MS; Fang, Shona C. ScD; Rodrigues, Ema G. PhD; Magari, Shannon R. ScD; Modest, Geoffrey A. MD; Christiani, David C. MD, MPH

Journal of Occupational and Environmental Medicine: October 2009 - Volume 51 - Issue 10 - p 1158-1166
doi: 10.1097/JOM.0b013e3181b967aa
Original Articles

Objective: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals.

Methods: Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG.

Results: Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day.

Conclusions: The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.

From the National Center for Environmental Assessment (Dr Kim), U.S. Environmental Protection Agency, Research Triangle Park, NC; Department of Environmental Health (Dr Kim, Dr Prouty, Dr Fang, Dr Rodrigues, Dr Magari, Dr Christiani), Environmental and Occupational Medicine and Epidemiology Program, Harvard School of Public Health, Boston, Mass; Department of Medicine (Dr Modest), Boston University School of Medicine, Boston, Mass; Upham’s Corner Health Center (Dr Modest), Dorchester, Mass; and Department of Medicine (Dr Christiani), Pulmonary and Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

This study was reviewed and approved by the Institutional Review Boards of the Harvard School of Public Health (Boston, MA) and Upham’s Corner Health Center (Dorchester, MA).

The views expressed in this paper are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency.

Address correspondence to: David C. Christiani, MD, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115; E-mail: dchris@hsph.harvard.edu.

©2009The American College of Occupational and Environmental Medicine