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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e3181b967aa
Original Articles

Association Between Fine Particulate Matter and Oxidative DNA Damage May Be Modified in Individuals With Hypertension

Kim, Jee Young ScD; Prouty, Lacey A. MS; Fang, Shona C. ScD; Rodrigues, Ema G. PhD; Magari, Shannon R. ScD; Modest, Geoffrey A. MD; Christiani, David C. MD, MPH

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Objective: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals.

Methods: Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG.

Results: Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day.

Conclusions: The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.

©2009The American College of Occupational and Environmental Medicine


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