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Multiple Myeloma in World Trade Center Responders: A Case Series

Moline, Jacqueline M. MD, MSc; Herbert, Robin MD; Crowley, Laura MD; Troy, Kevin MD; Hodgman, Erica BA; Shukla, Gauri MPH; Udasin, Iris MD; Luft, Benjamin MD; Wallenstein, Sylvan PhD; Landrigan, Philip MD, MSc; Savitz, David A. PhD

Journal of Occupational and Environmental Medicine: August 2009 - Volume 51 - Issue 8 - p 896-902
doi: 10.1097/JOM.0b013e3181ad49c8
Original Articles

Objectives: We report on cases of multiple myeloma (MM) observed in World Trade Center (WTC) responders registered in the WTC Medical Program.

Methods: Possible cases of MM diagnosed between September 11, 2001, and September 10, 2007, in responders were confirmed if they met the World Health Organization and Mayo Clinic diagnostic criteria.

Results: Among 28,252 responders of known sex and age, eight cases of MM were observed (6.8 expected). Four of these cases were observed in responders younger than 45 years at the time of diagnosis (1.2 expected). A slight deficit of MM cases was observed in responders older than 45 years (4 observed, 5.6 expected).

Conclusion: In this case series, we observe an unusual number of MM cases in WTC responders under 45 years. This finding underscores the importance of maintaining surveillance for cancer and other emerging diseases in this highly exposed population.

From the Department of Community and Preventive Medicine (Dr Moline, Dr Herbert, Dr Crowley, Dr Troy, Ms Hodgman, Ms Shukla, Dr Wallenstein, Dr Landrigan, Dr Savitz), Mount Sinai School of Medicine, New York, NY; Emory University School of Medicine (Ms Hodgman), Atlanta, Ga; Environmental and Occupational Health Sciences Institute (Dr Udasin), University of Medicine and Dentistry of New Jersey, Piscataway, NJ; Department of Medicine (Dr Luft), State University of New York at Stony Brook, Stony Brook, NY.

The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the CDC/NIOSH.

Address correspondence to: Jacqueline Moline, MD, MSc, 1 Gustave L. Levy Place, Box 1057, New York, NY 10029; E-mail:

©2009The American College of Occupational and Environmental Medicine