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Hearing Loss Among Licensed Pesticide Applicators in the Agricultural Health Study

Crawford, John Mac PhD; Hoppin, Jane A. ScD; Alavanja, Michael C. R. DrPH; Blair, Aaron PhD; Sandler, Dale P. PhD; Kamel, Freya PhD

Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e31816a8caf
Original Articles
Abstract

Objective: We evaluated self-reported hearing loss and pesticide exposure in licensed private pesticide applicators enrolled in the Agricultural Health Study in 1993 to 1997 in Iowa and North Carolina.

Methods: Among 14,229 white male applicators in 1999 to 2003, 4926 reported hearing loss (35%). Logistic regression was performed with adjustment for state, age, and noise, solvents, and metals. We classified pesticides by lifetime days of use.

Results: Compared with no exposure, the odds ratio (95% confidence interval) for the highest quartile of exposure was 1.19 (1.04 to 1.35) for insecticides and 1.17 (1.03 to 1.31) for organophosphate insecticides. Odds of hearing loss were elevated for high pesticide exposure events (1.38, 1.25 to 1.54), pesticide-related doctor visits (1.38, 1.17 to 1.62) or hospitalization (1.81, 1.25 to 2.62), and diagnosed pesticide poisoning (1.75, 1.36 to 2.26).

Conclusions: Although control for exposure to noise or other neurotoxicants was limited, this study extends previous reports suggesting that organophosphate exposure increases risk of hearing loss.

Author Information

From the Ohio State University College of Public Health (Dr Crawford), Columbus, Ohio; The National Institute of Environmental Health Sciences (Drs Hoppin, Sandler, and Kamel), NIH; and The National Cancer Institute (Drs Alavanja and Blair), NIH, Wash., DC.

Address correspondence to: John Mac Crawford, PhD, A332A Starling Loving Hall, 320 West Tenth Avenue, Columbus, OH 43210; E-mail: mcrawford@cph.osu.edu.

©2008The American College of Occupational and Environmental Medicine