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Urinary 8-Isoprostane and 8-OHdG Concentrations in Boilermakers With Welding Exposure

Nuernberg, Amy M. MD, MPH; Boyce, Paul D. MD, MPH; Cavallari, Jennifer M. ScD; Fang, Shona C. SM; Eisen, Ellen A. ScD; Christiani, David C. MD, MPH, MS

Journal of Occupational & Environmental Medicine: February 2008 - Volume 50 - Issue 2 - pp 182-189
doi: 10.1097/JOM.0b013e31815cf6cc
Original Articles

Objective: To investigate the association of exposure to fine particulate matter (PM2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes.

Methods: Forty-one workers were monitored over 24 hours during which baseline, postshift, bedtime, and next morning measurements were collected. Twenty-two workers participated as controls.

Results: Linear regression was used to model pairwise change in u-8-isoprostane and u-8-OHdG: pre- to postshift, preshift to bedtime, postshift to bedtime, and postshift to next morning. In the models, pre- to postshift change in 8-OHdG was statistically significant, whereas postshift to bedtime change in 8-isoprostane showed an unexpected inverse relationship with PM2.5.

Conclusions: Acute welding exposure is associated with a postshift blunting of systemic inflammation in chronically exposed boilermakers, as measured by 8-isoprostane. The level of oxidative DNA damage as measured by 8-OHdG is less clear.

From the Department of Environmental Health (Drs Nuernberg, Boyce, Cavallari, Eisen, Christiani, and Ms Fang), Harvard School of Public Health; and Pulmonary and Critical Care Unit (Drs. Nuernberg, Boyce, and Christiani), Massachusetts General Hospital/Harvard Medical School, Boston, Mass.

Address correspondence to: David Christiani, MD, MPH, MS, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Building 1, Room 1407, Boston, MA; E-mail: dchris@hohp.harvard.edu.

©2008The American College of Occupational and Environmental Medicine