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The Influence of Genetic Polymorphisms of GSTP1 on the Development of Asbestosis

Franko, Alenka MD, MSc; Dolžan, Vita MD, PhD; Arnerić, Niko MSc; Dodič-Fikfak, Metoda MD, PhD

Journal of Occupational & Environmental Medicine: January 2008 - Volume 50 - Issue 1 - pp 7-12
doi: 10.1097/JOM.0b013e31815cbab5
Original Articles

Objective: Genetic factors play an important role in the development of asbestosis. The aim of this study was to investigate whether genetic polymorphisms of glutathione S-transferase (GST) P1 represent a risk factor for this disease.

Methods: The study population included 262 workers with asbestosis and 265 matched controls. Information on cumulative asbestos exposure was available. A real-time PCR based on the 5′ nuclease assay was designed for the analysis of GSTP1 Ile105Val and Ala114Val polymorphisms.

Results: Asbestosis was associated with GSTP1 genotype coding for an enzyme with high conjugation capacity versus genotypes resulting in intermediate and low enzyme activity (odds ratio = 1.49, confidence interval = 1.06–2.10).

Conclusions: The key finding of the study was that GSTP1 genotype coding for an enzyme with high conjugation capacity significantly increases the risk of developing asbestosis.

From the Clinical Institute of Occupational Medicine (Dr Franko, Mr Arnerić, Dr Dodič-Fikfak), University Medical Center, Ljubljana, Slovenia; and Institute of Biochemistry (Dr Dolžan), Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Address correspondence to: Alenka Franko, MD, MSc, Clinical Institute of Occupational Medicine, University Medical Center, Ljubljana, Slovenia, Poljanski nasip 58, SI-1000 Ljubljana, Slovenia; E-mail: alenka.franko@siol.net.

©2008The American College of Occupational and Environmental Medicine