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Roles of Serum Clara Cell Protein 16 and Surfactant Protein-D in the Early Diagnosis and Progression of Silicosis

Wang, Shi-Xin PhD; Liu, Ping MMS; Wei, Mao-Ti MMS; Chen, Lei MMS; Guo, Yang MMS; Wang, Ran-Yang MMS; Tu, Zhi-Guang MMS; Liang, Xian-Cai BM

Journal of Occupational and Environmental Medicine: August 2007 - Volume 49 - Issue 8 - p 834-839
doi: 10.1097/JOM.0b013e318124a927
Original Articles

Objective: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis.

Methods: Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay.

Results: Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0+ and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0+, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%.

Conclusion: Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.

From the Proteomics Laboratory (Dr Wang, Mr Liu, Mr Wei, Mr Chen), Medical College of Chinese People’s Armed Police Force, Tianjin, China; Department of Laboratory Medicine (Mr Liu, Mr Chen, Mr Tu), Chong Qing University of Medical Science, Chongqing, China; Institute of Industrial Hygiene and Occupational Disease Control (Mr Guo), Tianjin Occupational Disease Hospital, Tianjin, China; Institute of Industrial Hygiene and Occupational Disease Control (Mr Wang), Tianjin Center for Disease Control and Prevention, Tianjin, China; CDC of Yangquan City (Mr Liang), Shan-Xi Province, Yang Quan, China.

Mao-Ti Wei and coauthors have no financial ties to the research presented here.

Address correspondence to: Maoti WEI, Proteomics Laboratory, Medical College of Chinese People’s Armed Police Force, Tianjin, China; E-mail: weimaoti@yahoo.com.cn.

©2007The American College of Occupational and Environmental Medicine