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Roles of Serum Clara Cell Protein 16 and Surfactant Protein-D in the Early Diagnosis and Progression of Silicosis

Wang, Shi-Xin PhD; Liu, Ping MMS; Wei, Mao-Ti MMS; Chen, Lei MMS; Guo, Yang MMS; Wang, Ran-Yang MMS; Tu, Zhi-Guang MMS; Liang, Xian-Cai BM

Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e318124a927
Original Articles
Abstract

Objective: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis.

Methods: Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay.

Results: Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0+ and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0+, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%.

Conclusion: Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.

Author Information

From the Proteomics Laboratory (Dr Wang, Mr Liu, Mr Wei, Mr Chen), Medical College of Chinese People’s Armed Police Force, Tianjin, China; Department of Laboratory Medicine (Mr Liu, Mr Chen, Mr Tu), Chong Qing University of Medical Science, Chongqing, China; Institute of Industrial Hygiene and Occupational Disease Control (Mr Guo), Tianjin Occupational Disease Hospital, Tianjin, China; Institute of Industrial Hygiene and Occupational Disease Control (Mr Wang), Tianjin Center for Disease Control and Prevention, Tianjin, China; CDC of Yangquan City (Mr Liang), Shan-Xi Province, Yang Quan, China.

Mao-Ti Wei and coauthors have no financial ties to the research presented here.

Address correspondence to: Maoti WEI, Proteomics Laboratory, Medical College of Chinese People’s Armed Police Force, Tianjin, China; E-mail: weimaoti@yahoo.com.cn.

©2007The American College of Occupational and Environmental Medicine