Skip Navigation LinksHome > August 2007 - Volume 49 - Issue 8 > Roles of Serum Clara Cell Protein 16 and Surfactant Protein-...
Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e318124a927
Original Articles

Roles of Serum Clara Cell Protein 16 and Surfactant Protein-D in the Early Diagnosis and Progression of Silicosis

Wang, Shi-Xin PhD; Liu, Ping MMS; Wei, Mao-Ti MMS; Chen, Lei MMS; Guo, Yang MMS; Wang, Ran-Yang MMS; Tu, Zhi-Guang MMS; Liang, Xian-Cai BM

Continued Medical Education
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Objective: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis.

Methods: Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay.

Results: Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0+ and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0+, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%.

Conclusion: Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.

©2007The American College of Occupational and Environmental Medicine


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