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Journal of Occupational & Environmental Medicine:
doi: 10.1097/JOM.0b013e318124a93f
Original Articles

Longitudinal Study of Serum Lipids and Liver Enzymes in Workers With Occupational Exposure to Ammonium Perfluorooctanoate

Sakr, Carine J. MD, MPH; Leonard, Robin C. PhD; Kreckmann, Kim H. BS; Slade, Martin D. MPH; Cullen, Mark R. MD

Continued Medical Education
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Abstract

Objective: To examine the relationship between serum perfluorooctanoate (PFOA), a biomarker of ammonium perfluorooctanoate exposure, and lipids and liver enzymes.

Methods: We conducted a longitudinal study on 454 workers and used mixed models to examine the relationship between serum PFOA and lipids and liver enzymes.

Results: One part per million (ppm) increase in serum PFOA was associated with a 1.06 mg/dL increase in total cholesterol, but was not associated with changes in triglycerides or other lipoproteins, after adjusting for potential confounders. Serum PFOA was also associated with total bilirubin (0.008 mg/dL decline/ppm) and serum aspartate aminotransferase (0.35 units increase/ppm) but not with the other liver enzymes.

Conclusions: These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.

©2007The American College of Occupational and Environmental Medicine

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