Skip Navigation LinksHome > November 2006 - Volume 48 - Issue 11 > Personal Coronary Risk Profiles Modify Autonomic Nervous Sys...
Journal of Occupational & Environmental Medicine:
doi: 10.1097/01.jom.0000245675.85924.7e
Original Articles

Personal Coronary Risk Profiles Modify Autonomic Nervous System Responses to Air Pollution

Chen, Jiu-Chiuan MD, MPH, ScD; Stone, Peter H. MD; Verrier, Richard L. PhD; Nearing, Bruce D. PhD; MacCallum, Gail BS; Kim, Jee-Young MS, ScD; Herrick, Robert F. ScD; You, Jinhong PhD; Zhou, Haibo PhD; Christiani, David C. MD, MPH, MS

Continued Medical Education
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Objective: We investigated whether PM2.5-mediated autonomic modulation depends on individual coronary risk profiles.

Methods: Five-minute average heart rate (HR) and heart rate variability (HRV, including standard deviation of normal-to-normal intervals [SDNN], square root of the mean squared differences of successive NN intervals [rMSSD], high frequency [HF]) were measured from 24-hour ambulatory electrocardiograms, and personal PM2.5 exposures were monitored in a prospective study of 10 male boilermakers (aged 34.3 ± 8.1 years). We used the Framingham score to classify individuals into low (score = 1–3) and high (score = 5–6) risk categories. Mixed-effect models were used for statistical analyses.

Results: Each 1-mg/m3 increase in the preceding 4-hour moving average PM2.5 was associated with HR increase (5.3 beats/min) and HRV reduction (11.7%, confidence interval [CI] = 6.2–17.1% for SDNN; 11.1%, CI = 3.1–19.1% for rMSSD; 16.6%, CI = 1.5–31.7% for HF). Greater responses (2- to 4-fold differences) were observed in high-risk subjects than in low-risk subjects.

Conclusions: Our study suggests that adverse autonomic responses to metal particulate are aggravated in workers with higher coronary risk profiles.

©2006The American College of Occupational and Environmental Medicine


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