Skip Navigation LinksHome > September 2006 - Volume 48 - Issue 9 > Associations Between Exposure to Polycyclic Aromatic Hydroca...
Journal of Occupational & Environmental Medicine:
doi: 10.1097/01.jom.0000226974.91335.5b
Original Articles

Associations Between Exposure to Polycyclic Aromatic Hydrocarbons and Temporal Change of Urinary 1-Hydroxypyrene Levels in Taiwanese Coke-Oven Workers

Lin, Ying-Chu PhD; Pan, Chih-Hong MSc; Chen, Chiou-Jong PhD; Wu, Kuen-Yuh PhD; Chang-Chien, Guo-Ping PhD; Ho, Chi-Kung PhD; Wu, Trong-Neng PhD; Chuang, Hong-Yi MD, PhD; Kuo, Hsien-Wen PhD; Wu, Ming-Tsang MD, PhD

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Abstract

Objectives: Our aim is to analyze the association between polycyclic aromatic hydrocarbon (PAH) exposure and the temporal change of urinary 1-hydroxypyrene (1-OHP).

Methods: Two personal air samples, eight spot urine samples, and questionnaires were used to collect PAH exposure, urinary 1-OHP, demographic data, and environmental pollutants.

Results: Topside-oven workers had significantly higher levels of PAH exposure and 1-OHP than side-oven workers. Urinary 1-OHP was a biomarker for PAH exposure. In topside-oven workers, the trend of 1-OHP increased sharply and reached the top in the sixth day after work and declined dramatically on days off. In side-oven workers, such a trend was not found, and those who smoked showed a slight increase in urinary 1-OHP levels on days off.

Conclusions: We suggest that the pattern of temporal change of urinary 1-OHP levels is different between topside-oven and side-oven workers.

©2006The American College of Occupational and Environmental Medicine

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