Objectives: Our aim is to analyze the association between polycyclic aromatic hydrocarbon (PAH) exposure and the temporal change of urinary 1-hydroxypyrene (1-OHP).
Methods: Two personal air samples, eight spot urine samples, and questionnaires were used to collect PAH exposure, urinary 1-OHP, demographic data, and environmental pollutants.
Results: Topside-oven workers had significantly higher levels of PAH exposure and 1-OHP than side-oven workers. Urinary 1-OHP was a biomarker for PAH exposure. In topside-oven workers, the trend of 1-OHP increased sharply and reached the top in the sixth day after work and declined dramatically on days off. In side-oven workers, such a trend was not found, and those who smoked showed a slight increase in urinary 1-OHP levels on days off.
Conclusions: We suggest that the pattern of temporal change of urinary 1-OHP levels is different between topside-oven and side-oven workers.
From the Graduate Institute of Dental Science (Mr Lin) and the Graduate Institute of Occupational Safety and Health (Dr Ho, Dr T-N Wu, Dr Chuang, Dr M-T Wu), Kaohsiung Medical University, Kaohsiung, Taiwan; the Institute of Occupational Safety and Health (Mr Pan, Dr Chen), Council of Labor Affairs, Taipei, Taiwan; the Division of Environmental Health and Occupational Medicine (Dr K-Y Wu), National Health Research Institute, Kaohsiung, Taiwan; the Department of Chemical Engineering (Dr Chang-Chien), Cheng Shiu University, Kaohsiung, Taiwan; and the Departments of Occupational Medicine and Family Medicine (Dr Kuo) and the Graduate Institute of Environmental Health (Dr M-T Wu), China Medical University & Hospital, Taichung, Taiwan.
Address correspondence to: Ming-Tsang Wu, MD, PhD, Departments of Occupational Medicine and Family Medicine, and Graduate Institute of Environmental Health, China Medical University & Hospital, 2, Yuh-Der Road, Taichung 404, Taiwan; E-mail: firstname.lastname@example.org.