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An Assessment of Fertility in Male Workers Exposed to Molinate

Tomenson, John A. PhD; Taves, Donald R. MD; Cockett, Abraham T.K. MD; McCusker, Jane MD; Barraj, Leila DSc; Francis, Marcie PhD; Pastoor, Timothy P. PhD; Wickramaratne, G. Ashley DeS. PhD; Northrop, Herbert L. MD

Journal of Occupational & Environmental Medicine: September 1999 - Volume 41 - Issue 9 - pp 771-787
Original Articles

Molinate is a thiocarbamate herbicide used for weed control in rice fields. Since the late 1970s, findings from reproductive toxicology studies of rats have led to concern that molinate might affect human male fertility. Semen samples were collected from 272 formulation and production workers at three US plants. The samples were collected at the end of four alternate monitoring periods of either high or low exposure to molinate. In addition, 222 married workers provided reproductive-history information. Workers' mean exposures to molinate during the monitoring periods ranged from 12.7 µg/m3 to 210.9 µg/m3. There was no evidence that sperm and serum hormone levels were related to exposure to molinate before the study or exposure during the four monitoring periods. There was also no evidence of a molinate exposure-related effect on the ratio of observed to expected births.

From the ICI Epidemiology Unit, Northwich, UK (Dr Tomenson); Department of Urology, University of Rochester Medical Center, Rochester, NY (Dr Cockett); the Department of Clinical Epidemiology and Community Studies, St Mary's Hospital Center, Montreal, Canada (Dr McCusker); Novigen Sciences Inc., Washington, DC (Dr Barraj); the Chlorine Chemistry Council, Arlington, Va. (Dr Francis); the Division of Regulatory Toxicology, Zeneca Agrochemical Products, Wilmington, Del. (Dr Pastoor); Zeneca Central Toxicology Laboratory, Alderley Edge, UK (Dr Wickramaratne); and Zeneca Pharmaceuticals, Wilmington, Del (Dr Northrop).

Address correspondence to: John A. Tomenson, PhD, ICI Epidemiology Unit, Brunner House, Winnington Lane, Winnington, Northwich, Cheshire, CW8 4DJ, UK.

© 1999 Lippincott Williams & Wilkins, Inc.