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Effects of 10-ppm Hydrogen Sulfide Inhalation on Pulmonary Function in Healthy Men and Women

Bhambhani, Yagesh PhD; Burnham, Robert MD; Snydmiller, Gary MSc; MacLean, Ian MSc; Lovlin, Ray PhD

Journal of Occupational & Environmental Medicine:
Original Article
Abstract

This study examined the acute effects of oral inhalation of 10-ppm hydrogen sulfide (H2S) inhalation (a concentration equal to its occupational exposure limit) on the pulmonary function in healthy men and women. Nine men and ten women consented to inhale medical air or 10 ppm H2S for 15 minutes each during cycle exercise at 50% of their maximal aerobic power. Routine pulmonary function tests were administered at rest and immediately after the two exposure conditions. The results indicated no significant changes in any of the variables derived from the flow volume loop, maximum ventilation volume, and diffusion capacity of the lung for carbon monoxide in both genders. None of the subjects experienced any signs and symptoms as a result of H2S exposure. It was concluded that oral inhalation of 10 ppm H2S at an elevated metabolic and ventilation rate does not significantly alter pulmonary function in healthy men and women.

Author Information

From the Department of Rehabilitation Medicine (Dr Bhambhani, Mr Snydmiller), the Department of Medicine (Dr Burnham), and the Department of Physical Education and Recreation (Mr MacLean, Dr Lovlin), University of Alberta, Edmonton, Alberta, Canada.

Address correspondence to: Yagesh Bhambhani, PhD, Faculty of Rehabilitation Medicine, Room 373, Corbett Hall, University of Alberta, Edmonton, Canada, T6G 2G4.

© Williams & Wilkins 1996. All Rights Reserved.