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Journal of Occupational Medicine:
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Patients with Suspected Solvent-Induced Encephalopathy Examined with Cerebral Computed Tomography

Ellingsen, Dag G. MD; Bekken, Marit MD; Kolsaker, Leif MD; Langard, Sverre MD, MSc

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Abstract

: The aim of this study was to investigate the relationship between organic solvent exposure and brain atrophy among 85 patients referred to a department of occupational medicine and who underwent cerebral computed tomography. On average, the patients had been heavily exposed to a mixture of organic solvents for 22.9 years. Diseases which may be associated with brain atrophy or high alcohol consumption was observed among 31% of the subjects. Among these subjects the prevalence of brain atrophy was 58%. The prevalence of brain atrophy was 20% among the men without such conditions. None of the eight female patients appeared to have atrophy. The quantitative assessment showed no correlation between the duration of exposure and atrophy-related parameters. However, the width of the third ventricle, bifrontal ratio, and bicaudate ratio were correlated with age.

(C)1993 The American College of Occupational and Environmental Medicine

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