The primary purpose of this study was to examine the effects of an intervention consisting of the four translation strategies of educational materials, educational meetings, reminders, and audit and feedback on nurses’ adoption of an evidence-based bladder program for patients with stroke in an acute care setting. The secondary purpose was to evaluate the difference in incontinence episodes of patients with stroke before and after nurses received the intervention. Finally, the purpose was to evaluate the influence of nurses’ attitudes and the demographic characteristics on the adoption and use of the evidence-based bladder program after receiving the intervention. This study was the first to provide empirical support for the influence of the combination of these four translation strategies and nurses’ attitudes toward research on the adoption of evidence-based practice in a time-series design study. Thus, the combined use of the four translation strategies did have an impact on nurses’ adoption of evidence-based practice.