ABSTRACT: Hyperglycemia is a common complication that many critically ill patients experience. The increase in serum glucose is known to result in higher mortality and morbidity rates. Recent research has established that there is a benefit in using tight glycemic control protocols for critically ill patients. However, whether treatment guidelines benefit all patient populations remains unclear. Specifically, neurological injuries are known to require adequate glucose to repair cerebral metabolism, making the idea of tight glycemic control controversial. This article will analyze current research relevant to the use of strict glycemic control protocols for the neurologically injured patient by comparing population characteristics, methods, and outcomes to determine whether there is enough evidence to support its implementation in advanced nursing practice.