ABSTRACT: All neuroscience nurses must be able to evaluate different avenues to inform their practice and solve clinical problems. The three methodologies discussed in this article have particular strengths in certain situations and require different skill sets, time, and resources. Quality improvement, evidence-based practice, and research are interconnected and inform each other. It can be difficult at times for the practitioners to identify the right method to answer clinical questions. The state of readiness for frontline staff to manage clinical problems with evidence-based practice and research must be advanced for the scientific knowledge employed by our profession to be visible in our clinical care.