Acute stroke can result in neurological impairment and potentially death. The Colorado Stroke Alliance has made significant progress in improving stroke care through their statewide quality improvement efforts. The following provides an overview of how this effort has come to fruition. Included is an overview of the collaboration, an explanation of the organizational structure, the source of funding, a description of the statewide quality efforts improvement including mentoring and data reporting, and an overview of nursing involvement. This discussion highlights how a relatively small task force has transformed into a growing nonprofit organization, becoming a model for best practices.