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Cladribine Tablets' Potential in Multiple Sclerosis Treatment

Costello, Kathleen; Sipe, Jack C.

Journal of Neuroscience Nursing: October 2008 - Volume 40 - Issue 5 - p 275–280
Then & Now

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system occurring in genetically susceptible individuals. T and B lymphocytes are thought to be important in the pathogenesis of MS. Among the unmet needs in MS therapeutics are agents with improved efficacy and safety profiles and improved routes of administration. Cladribine, which is a preferential lymphocyte‐depleting therapy, has the potential to be the first oral agent available for the treatment of relapsing forms of MS. This oral formulation is administered through intermittent, once‐daily dosing to treat relapsing forms of MS. Cladribine as a parenteral formulation has extensive clinical experience for other disease states including hematologic malignancies and relapsing and progressive forms of MS. Cladribine tablets now are undergoing phase III development for the treatment of relapsing forms of MS. With the advent of new MS agents such as cladribine tablets, nurses will be critical in monitoring these new therapies.

Questions or comments about this article may be directed to Kathleen Costello, MS CRNP MSCN, KCostello@som.umaryland.edu. She is a nurse practitioner and MS program director at Maryland Center for Multiple Sclerosis Treatment and Research at the University of Maryland, Baltimore.

Jack C. Sipe, MD, is a senior consultant in neurology at the Scripps Clinic and associate professor of neurology in the Department of Molecular and Experimental Medicine at the Scripps Research Institute, La Jolla, CA.

© 2008 American Association of Neuroscience Nurses