Skip Navigation LinksHome > May 2014 - Volume 73 - Issue 5 > IgG and Complement Deposition and Neuronal Loss in Cats and...
Journal of Neuropathology & Experimental Neurology:
doi: 10.1097/NEN.0000000000000063
Original Articles

IgG and Complement Deposition and Neuronal Loss in Cats and Humans With Epilepsy and Voltage-Gated Potassium Channel Complex Antibodies

Klang, Andrea DVM; Schmidt, Peter DVM; Kneissl, Sibylle DVM; Bagó, Zoltán DVM; Vincent, Angela MD; Lang, Bethan PhD; Moloney, Teresa PhD; Bien, Christian G. MD; Halász, Péter PhD; Bauer, Jan PhD; Pákozdy, Ákos DVM, DECVN

Collapse Box

Abstract

Voltage-gated potassium channel complex (VGKC-complex) antibody (Ab) encephalitis is a well-recognized form of limbic encephalitis in humans, usually occurring in the absence of an underlying tumor. The patients have a subacute onset of seizures, magnetic resonance imaging findings suggestive of hippocampal inflammation, and high serum titers of Abs against proteins of the VGKC-complex, particularly leucine-rich, glioma-inactivated 1 (LGI1). Most patients are diagnosed promptly and recover substantially with immunotherapies; consequently, neuropathological data are limited. We have recently shown that feline complex partial cluster seizures with orofacial involvement (FEPSO) in cats can also be associated with Abs against VGKC-complexes/LGI1. Here we examined the brains of cats with FEPSO and compared the neuropathological findings with those in a human with VGKC-complex-Ab limbic encephalitis. Similar to humans, cats with VGKC-complex-Ab and FEPSO have hippocampal lesions with only moderate T-cell infiltrates but with marked IgG infiltration and complement C9neo deposition on hippocampal neurons, associated with neuronal loss. These findings provide further evidence that FEPSO is a feline form of VGKC-complex-Ab limbic encephalitis and provide a model for increasing understanding of the human disease.

Copyright © 2014 by the American Association of Neuropathologists, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.