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Journal of Neuropathology & Experimental Neurology:
doi: 10.1097/NEN.0000000000000032
Original Articles

Long-Term High-Level Exercise Promotes Muscle Reinnervation With Age

Mosole, Simone BS; Carraro, Ugo MD; Kern, Helmut MD; Loefler, Stefan Eng; Fruhmann, Hannah PT; Vogelauer, Michael MD; Burggraf, Samantha Eng; Mayr, Winfried PhD; Krenn, Matthias DI; Paternostro-Sluga, Tatjana PhD; Hamar, Dusan MD; Cvecka, Jan PhD; Sedliak, Milan PhD; Tirpakova, Veronika PhD; Sarabon, Nejc PhD; Musarò, Antonio PhD; Sandri, Marco MD; Protasi, Feliciano PhD; Nori, Alessandra PhD; Pond, Amber PhD; Zampieri, Sandra PhD

Supplemental Author Material
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Abstract

The histologic features of aging muscle suggest that denervation contributes to atrophy, that immobility accelerates the process, and that routine exercise may protect against loss of motor units and muscle tissue. Here, we compared muscle biopsies from sedentary and physically active seniors and found that seniors with a long history of high-level recreational activity up to the time of muscle biopsy had 1) lower loss of muscle strength versus young men (32% loss in physically active vs 51% loss in sedentary seniors); 2) fewer small angulated (denervated) myofibers; 3) a higher percentage of fiber-type groups (reinnervated muscle fibers) that were almost exclusive of the slow type; and 4) sparse normal-size muscle fibers coexpressing fast and slow myosin heavy chains, which is not compatible with exercise-driven muscle-type transformation. The biopsies from the old physically active seniors varied from sparse fiber-type groupings to almost fully transformed muscle, suggesting that coexpressing fibers appear to fill gaps. Altogether, the data show that long-term physical activity promotes reinnervation of muscle fibers and suggest that decades of high-level exercise allow the body to adapt to age-related denervation by saving otherwise lost muscle fibers through selective recruitment to slow motor units. These effects on size and structure of myofibers may delay functional decline in late aging.Trial registration: ClinicalTrials.gov (NCT01679977).

Copyright © 2014 by the American Association of Neuropathologists, Inc.

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