Home Current Issue Previous Issues Published Ahead-of-Print Collections For Authors Journal Info
Skip Navigation LinksHome > November 2011 - Volume 70 - Issue 11 > α-Internexin in the Diagnosis of Oligodendroglial Tumors and...
Journal of Neuropathology & Experimental Neurology:
doi: 10.1097/NEN.0b013e3182333ef5
Original Articles

α-Internexin in the Diagnosis of Oligodendroglial Tumors and Association With 1p/19q Status

Eigenbrod, Sabina MD; Roeber, Sigrun MD; Thon, Niklas MD; Giese, Armin MD; Krieger, Anna; Grasbon-Frodl, Eva MD; Egensperger, Rupert MD; Tonn, Jörg-Christian MD; Kreth, Friedrich-Wilhelm MD; Kretzschmar, Hans A. MD, FRCPath

Collapse Box

Abstract

α-Internexin (INA) has been proposed to be a surrogate marker for the 1p/19q codeletion in oligodendroglial tumors (OTs). We analyzed INA expression in 83 glioma and 21 oligodendroglial phenotype-mimicking tumors (OMT) to assess its usefulness in differential diagnosis and its correlation with 1p/19q status; in particular, INA expression in gliomas with isolated/partial 1p or 19q deletions was assessed. α-Internexin expression and 1p/19q codeletion were present in 92% (34/37) of codeleted tumors (p < 0.0001). By contrast, INA was found in only 20% of cases with isolated/partial 1p aberrations and 36% of cases without 1p/19q deletions; it was also foundin 63% (10/16) of cases with isolated/partial 19q aberrations. α-Internexin expression was more specific in high-grade than in low-grade gliomas (66% vs 31%). Notably, a subset of tumors (10/83) displayed a biphasic INA expression pattern that was significantly associated with proliferation rate, whereas all areas harbored the 1p/19q codeletion. Only no or weak INA expression was seen in OMTs. In summary, INA is a useful marker to differentiate OTs from astrocytic tumors and OMTs, but INA expression is not exclusively linked to OTs harboring the 1p/19q codeletion. Moreover, it can sometimes be heterogeneously distributed within tumors, which emphasizes the need for 1p/19q analysis by molecular genetic techniques for diagnosis.

© 2011 American Association of Neuropathologists, Inc

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.