Skip Navigation LinksHome > October 2011 - Volume 70 - Issue 10 > Bacterial Meningitis Impairs Hippocampal Neurogenesis
Journal of Neuropathology & Experimental Neurology:
doi: 10.1097/NEN.0b013e3182303f31
Original Articles

Bacterial Meningitis Impairs Hippocampal Neurogenesis

Hofer, Sandra PhD; Grandgirard, Denis PhD; Burri, Denise MSc; Fröhlich, Tanja K. MSc; Leib, Stephen L. MD

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Abstract

Bacterial meningitis causes persisting neurofunctional sequelae. The occurrence of apoptotic cell death in the hippocampal subgranular zone of the dentate gyrus characterizes the disease in patients and relates to deficits in learning and memory in corresponding experimental models. Here, we investigated why neurogenesis fails to regenerate the damage in the hippocampus associated with the persistence of neurofunctional deficits. In an infant rat model of bacterial meningitis, the capacity of hippocampal-derived cells to multiply and form neurospheres was significantly impaired compared to that in uninfected littermates. In an in vitro model of differentiating hippocampal cells, challenges characteristic of bacterial meningitis (i.e. bacterial components, tumor necrosis factor [20 ng/mL], or growth factor deprivation) caused significantly more apoptosis in stem/progenitor cells and immature neurons than in mature neurons. These results demonstrate that bacterial meningitis injures hippocampal stem and progenitor cells, a finding that may explain the persistence of neurofunctional deficits after bacterial meningitis.

© 2011 American Association of Neuropathologists, Inc

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