Abstract: A 20-year-old woman infected with the 2009 H1N1 strain of influenza A developed bilateral visual loss. Brain MRI showed restricted diffusion of the parietal and occipital lobes, and her spinal fluid did not contain inflammatory cells. This report describes an unusual case of H1N1 influenza A virus infection primarily affecting the posterior visual pathways.
Departments of Neurology and Neuro-ophthalmology (JHP, JCK), Neurosurgery (AI), and Radiology (JRD), University of Illinois College of Medicine at Peoria, Peoria, Illinois.
Address correspondence to John H. Pula, MD, Department of Neurology and Neuro-ophthalmology, University of Illinois College of Medicine at Peoria, 530 NE Glen Oak Avenue, Peoria, IL 61637; E-mail: firstname.lastname@example.org
The authors report no conflicts of interest.
A 20-year-old woman with Type I diabetes mellitus reported 1 week of malaise and fatigue. On initial examination, her blood pressure was 106/66 mm Hg; pulse rate, 114 beats per minute; temperature, 101.9°F; respirations, 51 per minute; and pulse oximeter oxygen saturation, 92%. Arterial blood gas PO2 was 68 mm Hg (normal, 75–90 mm Hg); PCO2, 24 mm Hg (normal, 35–45 mm Hg); glucose, 193 mg/dL (normal, 70–99 mg/dL); and creatinine, 2.82 mg/dL (normal, 0.6–1 mg/dL). Chest X-ray showed bilateral patchy infiltrates. Real-time polymerase chain reaction (PCR) sampled from pharyngeal mucosa tested positive for H1N1 influenza virus.
The patient was admitted to hospital and given intravenous fluids, piperacillin/tazobactam, azithromycin, and oseltamivir. Because of respiratory distress, she was intubated, sedated with midazolam and fentanyl, and required an oscillator for 7 days, with traditional ventilation for an additional 10 days. Her creatinine normalized. Blood cultures showed no growth. She developed a hospital-acquired fungal urinary tract infection treated with fluconazole but remained normotensive and hemodynamically stable.
On Hospital Day 17, she was extubated and stated that she could not see. On neurologic examination, the patient was mildly agitated and irritable. Visual acuity was hand motions in each eye. External, pupillary, and funduscopic examinations were normal.
The following day, brain MRI demonstrated signal abnormalities involving the posterior parietal and occipital cortex bilaterally (Fig. 1). There was mild patchy enhancement in regions of signal abnormality without evidence of hemorrhage on gradient echo, nor evidence of cerebral venous thrombosis on T1-weighted imaging. Electroencephalography showed periodic lateralizing epileptiform discharges from the right hemisphere. Cerebrospinal fluid (CSF) analysis showed no white or red blood cells, glucose was 78 mg/dL (normal, 40–70 mg/dL), and protein was 110 mg/dL (normal, 12–60 mg/dL). CSF HSV PCR, cryptococcal screen, Gram stain, and bacterial culture were negative.
On Hospital Day 20, the patient became drowsy and agitated and required reintubation for worsening respiratory function. One week later, she was extubated, and on the following day, she was alert with visual acuity of J5 in both eyes with normal pupillary testing and funduscopy. Brain MRI with FLAIR sequences showed signal abnormalities in the occipital lobes bilaterally (Fig. 2).
The patient had no further respiratory decompensation but maintained a persistently flat affect. Neuropsychologic examination showed moderately reduced cognitive function. Simple auditory attention was preserved. However, on tasks requiring visual attention and speed, her performance was moderately to severely impaired. Abstract visual construction was also decreased.
There are 3 types of influenza virus: A, B, and C. Influenza A is an enveloped RNA virus of multiple strains and is named for which subtypes of hemagglutinin and neurominidase antigen are on its surface. These subtypes include H1N1, H1N2, H3N1, H3N2, and H2N3 (1). Episodically, influenza A H1N1 strains have caused outbreaks of human disease. For example, the 1918 Spanish flu epidemic implicated in encephalitis lethargica was triggered by an H1N1 strain (1).
In 2009, a genetically distinct strain of H1N1 influenza A became pandemic. This strain clinically manifested mainly with respiratory problems, especially in young people. Neurologic complications of the 2009 H1N1 strain occurred primarily in children, resulting in seizures and encephalopathy (2,3). Focal neurologic problems such as hemisensory loss caused from H1N1 were less commonly reported (4,5). Despite neurologic involvement, CSF analysis in these patients was often normal (6–9). In our patient, the elevated protein but otherwise unremarkable CSF is consistent with the CSF profile from other H1N1 encephalopathy patients (6,10).
Neuroimaging abnormalities from influenza A encephalitis may be due to several mechanisms. Hypoxic or anoxic damage as a result of respiratory dysfunction can lead to CNS ischemia or infarction (10). Alternatively, CNS damage may be due to a direct infectious or parainfectious process related to the H1N1 virus. Mainly described in children, these parainfectious syndromes range from acute demyelinating encephalomyelitis to more hyperacute states, such as acute hemorrhagic leukoencephalopathy (4).
Probably related, acute necrotizing encephalopathy is a syndrome mainly described in East Asian children, resulting in seizures, fever, and coma (11). Brain imaging typically demonstrates bilateral symmetric lesions of the thalami, white matter, and brainstem (7,12). In such a case, autopsy findings showed vasculopathy and necrotizing lesions of white matter, basal ganglia, thalami, and brainstem (13).
Neuroimaging abnormalities associated with the pandemic 2009 H1N1 strain have been reported infrequently, usually in children (4,10,14,15). Not all neurologic symptoms occurring in H1N1 patients produce MRI changes (5). In a series of 8 children with H1N1 encephalopathy, only 3 showed bilateral lesions of the thalami and white matter on MRI (16). Lyon et al (17) described the case of a 12-year-old girl with H1N1 encephalopathy who developed seizures and lethargy and had bilateral thalamic and brainstem MRI lesions. Haktanir (15) reported a 3-year-old girl with bilateral thalamic and brainstem T2 hyperintensities, which showed restricted diffusion on diffusion-weighted imaging (DWI). Occipital lobe involvement due to H1N1 has been documented in 2 previously reported cases, but the young age of both patients precluded accurate assessment of visual function (18,19).
The neuroimaging abnormalities in our patient raised the possibility of posterior reversible encephalopathy syndrome. Yet the lack of clinical improvement and cytotoxic edema found on DWI are both inconsistent with this diagnosis. Hypoxia also could result in restricted diffusion but would produce imaging findings of cortical laminar necrosis, which were not present in our patient. Finally, cerebral ischemia was considered, but the vascular territories involved are not representative of hypotension or arterial thromboembolism, and there was no evidence of venous thrombosis. Thus, the pattern of symmetrical MRI abnormalities with restricted diffusion in our case most likely represents a parainfectious encephalopathy.
1. Morens DM, Taubenberger JK, Fauci AS. The persistent legacy of the 1918 influenza virus. N Engl J Med. 2010;361:225–229
2. Brock E, Varghese A, Miller L. Neurologic complications associated with novel influenza A (H1N1) virus infection in children: Dallas, Texas, May 2009. MMWR Morb Mortal Wkly Rep. 2009;58:773–778
3. Sejvar JJ, Uyeki TM. Neurologic complications of 2009 influenza A (H1N1). Neurology. 2010;74:1020–1021
4. Wang J, Duan S, Zhao J, Zhang L. Acute disseminated encephalomyelitis associated with influenza A H1N1 infection. Neurol Sci. 2011;32:907–909
5. Tan K, Prema A, Leo YS. Surveillance of H1N1-related neurological complications. Lancet Neurol. 2010;9:142–143
6. Al-Baghli F, Al-Ateeqi W. Encephalitis-associated pandemic A (H1N1) 2009 in a Kuwaiti girl. Med Princ Pract. 2011;20:191–195
7. Fujimoto Y, Shibata M, Tsuyuki M, Okada M, Tsuzuki K. Influenza A virus encephalopathy with symmetrical thalamic lesions. Eur J Pediatr. 2000;159:319–321
8. Morishima T, Togashi T, Yokota S, Okuno Y, Miyazaki C, Tashiro M, Okabe NCollaborative Study Group on Influenza-Associated Encephalopathy in Japan. . Encephalitis and encephalopathy associated with an influenza epidemic in Japan. Clin Infect Dis. 2002;35:512–517
9. Gadoth A, Aizenstein O, Mosek A. Influenza A/H1N1 encephalitis. Neurology. 2010;75:666–667
10. Fugate J, Lam E, Rabinstein A, Wijdicks E. Acute hemorrhagic leukoencephalitis and hypoxic brain injury associated with H1N1 influenza. Arch Neurol. 2010;67:756–758
11. Ormitti F, Ventura E, Summa A, Picetti E, Crisi G. Acute necrotizing encephalopathy in a child during the 2009 influenza A(H1N1) pandemia: MR imaging in diagnosis and follow-up. AJNR Am J Neuroradiol. 2010;31:396–400
12. Protheroe SM, Mellor DH. Imaging in influenza A encephalitis. Arch Dis Child. 1991;66:702–705
13. Ng WF, Chiu SC, Lam DSY, Wong YC, Tam S, Kwong NS, Loo KT, Yuen KY. A 7-year-old boy dying of acute encephalopathy. Brain Pathol. 2010;20:261–264
14. Chen Y, Lo C, Chang T. Novel influenza A (H1N1)-associated encephalopathy/encephalitis with severe neurological sequelae and unique image features—a case report. J Neurol Sci. 2010;298:110–113
15. Haktanir A. MR imaging in novel influenza A(H1N1)-associated meningoencephalitis. Am J Neuroradiol. 2010;31:394–395
16. Zhao C, Gan Y, Sun J. Radiographic study of severe influenza-A (H1N1) disease in children. Eur J Radiol. 2011;79:447–451
17. Lyon JB, Remigio C, Milligan T, Deline C. Acute necrotizing encephalopathy in a child with H1N1 influenza infection. Pediatr Radiol. 2010;40:200–205
18. Sandoval-Gutierrez JL, Arcos M, Alva L, Volkow P, Ferrari T, Quinones F, Vazquez-Perez J, Ormsby CE, Hanssen F, Resendiz A, Alcantar P, Perez Padilla R, Bautista E. Letter to the editor. Ann Neurol. 2011;69:217–218
19. Mariotti P, Iorio R, Frisullo G, Plantone D, Colantonio R, Tartaglione T, Batocchi AP, Valentini P. Acute necrotizing encephalopathy during novel influenza A (H1N1) virus infection. Ann Neurol. 2010;68:111–114