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Relative Frequencies of Arteritic and Nonarteritic Anterior Ischemic Optic Neuropathy in an Arab Population

Gruener, Anna M. BMBS, MSc, FRCOphth; Chang, Jessica R. MD; Bosley, Thomas M. MD; Al-Sadah, Zakeya M. MD; Kum, Clarissa OD; McCulley, Timothy J. MD

doi: 10.1097/WNO.0000000000000491
Original Contribution

Background: To evaluate the relative frequencies of arteritic and nonarteritic anterior ischemic optic neuropathy (AION) in an Arab population and to compare and contrast these findings with known epidemiological data from Caucasian populations.

Methods: A retrospective review of the medical records of all patients diagnosed with AION at the King Khaled Eye Specialist Hospital (KKESH) in Riyadh, Saudi Arabia, between 1997 and 2012.

Results: Of 171 patients with AION, 4 had biopsy-proven giant-cell arteritis (GCA). The relative frequencies of arteritic anterior ischemic optic neuropathy (AAION) and nonarteritic anterior ischemic optic neuropathy (NAION) in this Arab cohort were 2.3% and 97.7%, respectively.

Conclusions: The relative frequencies of arteritic anterior ischemic optic neuropathy and nonarteritic anterior ischemic optic neuropathy differ between Arab and North American clinic-based populations, with giant-cell arteritis-related ischemia being much less frequent in Saudi Arabia.

The Neuro-Ophthalmology Division (AMG, JRC, TMB, CK, TJM), Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, MD; and Neuro-Ophthalmology Division (TMB, ZMA-S, TJM), King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Address correspondence to Timothy J. McCulley, MD, 600 North Wolfe Street, Wilmer 110, Baltimore, MD 21287; E-mail: tmccull5@jhmi.edu

The authors report no conflict of interests.

© 2017 by North American Neuro-Ophthalmology Society