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Positional Suppression of Periodic Alternating Nystagmus

Chung, Seok Jong MD; Park, Seong-Ho MD, PhD; Kim, Ji-Soo MD, PhD; Oh, Sea Won BSc; Kim, Hyo Jung MSc; Park, Jae Han MD; Huh, Young Eun MD

Journal of Neuro-Ophthalmology: June 2014 - Volume 34 - Issue 2 - p 162–164
doi: 10.1097/WNO.0000000000000098
Clinical Observation

Abstract: A 43-year-old man with a high-grade glioma involving the cerebellar nodulus showed a near-complete suppression of periodic alternating nystagmus (PAN) in the lateral decubitus position to either side. This positional modulation of PAN is consistent with suppression of the velocity storage mechanism by head position changes (tilt dumping) and is supportive of the role of the velocity storage mechanism in generating PAN.

Department of Neurology (SJC), Yonsei University College of Medicine, Seoul, Korea; Department of Neurology (S-HP, J-SK, SWO, HJK, JHP, YEH), Seoul National University Bundang Hospital, Seongnam-si, Korea; and Department of Neurology (S-HP, J-SK), Seoul National University College of Medicine, Seoul, Korea.

Address correspondence to Ji-Soo Kim, MD, PhD, Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea; E-mail:

S. J. Chung, MD and S-H. Park equally contributed to this study.

S. J. Chung, S-H. Park, S. W. Oh, H. J. Kim, J. H. Park, and Y. E. Huh report no disclosures. J. S. Kim serves as an Associate Editor of Frontiers in Neuro-otology and on the editorial boards of the Journal of Neuro-ophthalmology, Journal of Clinical Neurology, Frontiers in Neuro-ophthalmology, and Journal of Vestibular Research; and received research support from SK Chemicals, Co. Ltd.

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Supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A080750).

© 2014 by North American Neuro-Ophthalmology Society