Abstract: Castleman disease is a rare lymphoproliferative disorder that has many presentations ranging from unifocal or multifocal mass lesions to a monoclonal gammopathy. It has features that may overlap with osteosclerotic myeloma or POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome. We report a patient with papilledema, enlarged lymph nodes, and monoclonal IgG, who subsequently developed a polyneuropathy. Biopsy of enlarged mediastinal lymph nodes confirmed the diagnosis of Castleman disease.
Department of Ophthalmology (GT), Eye and ENT Hospital, Fudan University, Shanghai, China; and Departments of Neurology (YJ, HJ, XZ) and Hematology (JW), Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Address Correspondence to Xiaojun Zhang, MD, PhD, Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No.1 Dong Jiao Min Xiang Street, Dongcheng District, Beijing 100730, China; E-mail: email@example.com
The authors report no conflicts of interest.