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Journal of Neuro-Ophthalmology:
doi: 10.1097/WNO.0000000000000096
Clinical Observation

Papilledema as the Initial Presentation of Castleman Disease

Tian, Guohong MD, PhD; Jing, Yun MD, PhD; Jiang, Hanqiu MD, PhD; Wang, Jingwen MD, PhD; Zhang, Xiaojun MD, PhD

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Abstract

Castleman disease is a rare lymphoproliferative disorder that has many presentations ranging from unifocal or multifocal mass lesions to a monoclonal gammopathy. It has features that may overlap with osteosclerotic myeloma or POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome. We report a patient with papilledema, enlarged lymph nodes, and monoclonal IgG, who subsequently developed a polyneuropathy. Biopsy of enlarged mediastinal lymph nodes confirmed the diagnosis of Castleman disease.

Copyright © 2014 by North American Neuro-Ophthalmology Society

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