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Papilledema as the Initial Presentation of Castleman Disease

Tian, Guohong MD, PhD; Jing, Yun MD, PhD; Jiang, Hanqiu MD, PhD; Wang, Jingwen MD, PhD; Zhang, Xiaojun MD, PhD

Journal of Neuro-Ophthalmology: June 2014 - Volume 34 - Issue 2 - p 169–172
doi: 10.1097/WNO.0000000000000096
Clinical Observation

Abstract: Castleman disease is a rare lymphoproliferative disorder that has many presentations ranging from unifocal or multifocal mass lesions to a monoclonal gammopathy. It has features that may overlap with osteosclerotic myeloma or POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome. We report a patient with papilledema, enlarged lymph nodes, and monoclonal IgG, who subsequently developed a polyneuropathy. Biopsy of enlarged mediastinal lymph nodes confirmed the diagnosis of Castleman disease.

Department of Ophthalmology (GT), Eye and ENT Hospital, Fudan University, Shanghai, China; and Departments of Neurology (YJ, HJ, XZ) and Hematology (JW), Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Address Correspondence to Xiaojun Zhang, MD, PhD, Department of Neurology, Beijing Tongren Hospital, Capital Medical University, No.1 Dong Jiao Min Xiang Street, Dongcheng District, Beijing 100730, China; E-mail:

The authors report no conflicts of interest.

© 2014 by North American Neuro-Ophthalmology Society