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Detection of Thyroid Abnormalities in Aquaporin-4 AntibodySeropositive Optic Neuritis Patients

Zhao, Shuo MD; Zhou, Huanfen MD; Peng, Xudong MD; Tan, Shaoying PhD, MD; Liu, Zihao MD; Chen, Tingjun PhD, MD; Xu, Quangang PhD, MD; Wei, Shihui MD

Journal of Neuro-Ophthalmology: March 2017 - Volume 37 - Issue 1 - p 24–29
doi: 10.1097/WNO.0000000000000454
Original Contribution

Objective: This study retrospectively analyzed the frequency of anti-thyroid antibodies (ATAs) and thyroid disease in patients with optic neuritis (ON).

Methods: Tests of serum thyroglobulin (TG) and thyroid peroxidase (TPO) antibodies and thyroid function were performed in 97 ON patients. Blood also was drawn to test for AQP4-Ab using cell-based and enzyme-linked immunosorbent assays. Comparisons of the frequencies of ATAs, thyroid diseases and thyroid function were performed based on AQP4-Ab status.

Results: Seropositive AQP4-Ab was found in 47/97 (48.5%) patients. ATA was considered positive in 34/97 (35.1%) patients. The prevalence of ATA was two times higher (P = 0.019) in the AQP4-Ab+ group compared to the AQP4-Ab- group. AQP4-Ab+ ON patients exhibited lower FT3 (P = 0.006) and FT4 (P = 0.025) levels and a higher prevalence of definite Hashimoto thyroiditis (HT) (P = 0.005). Among AQP4-Ab+ patients, those with HT had a worse visual outcome than non-HT patients.

Conclusion: A high prevalence of ATAs and HT was found in AQP4-Ab+ ON patients, and AQP4-Ab+ patients with HT exhibited worse visual outcomes than non-HT patients.

Department of Ophthalmology (SZ), Beijing Hospital, Beijing, China; Department of Ophthalmology (HZ), The First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing, China; Department of Ophthalmology (ST, TC, QX, SW), The Chinese People's Liberation Army General Hospital, Beijing, China; Department of Health Care (XP), The Chinese People's Liberation Army General Staff Department Guard Bureau, Beijing, China; and Department of Ophthalmology (ZL), The Chinese Dongzhimen Hospital, Beijing, China.

Address correspondence to Shihui Wei, MD, Department of Neuro-Ophthalmology, The People's Liberation Army General Hospital, Beijing, China; E-mail: dr_weishihui@163.com

Supported by the National High Technology Research and Development Program of China (No. 2015AA020511) and the Hainan Technology and Society Development Program of China (No. SQ2014SHFZ0089).

The authors report no conflicts of interest.

S. Zhao, H. Zhou, and X. Peng contributed equally to this study.

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

© 2017 by North American Neuro-Ophthalmology Society