Journal of Neuro-Ophthalmology

Skip Navigation LinksHome > September 2013 - Volume 33 - Issue 3 > Congenital Mydriasis Associated With Megacystis Microcolon I...
Journal of Neuro-Ophthalmology:
doi: 10.1097/WNO.0b013e31828b7d65
Clinical Observation

Congenital Mydriasis Associated With Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

McClelland, Collin MD; Walsh, Ryan D. MD; Chikwava, Kudakwashe R. MBChB; Johnson, Mark P. MD, MS; Mattei, Peter MD, FACS, FAAP; Liu, Grant T. MD

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Abstract: We report a case of congenital mydriasis in a neonate with megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS). Pilocarpine testing and gastrointestinal pathology in our patient suggest that the mydriasis is due to an underlying smooth muscle myopathy of the iris sphincter muscle. These findings may have important implications regarding the pathogenesis of MMIHS.

© 2013 by North American Neuro-Ophthalmology Society


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