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A Resting State Functional Magnetic Resonance Imaging Study of Patients With Benign Essential Blepharospasm

Zhou, Bo; Wang, Jinyu; Huang, Yulan; Yang, Yousong; Gong, Qiyong; Zhou, Dong

doi: 10.1097/WNO.0b013e31828f69e5
Original Contribution
Japanese Abstract

Background: Benign essential blepharospasm (BEB) is a neurologic disorder characterized by an adult-onset focal dystonia that causes involuntary blinking and eyelid spasms. The pathophysiology of BEB patients remains unclear. This study investigated intrinsic low-frequency fluctuation in BEB patients during resting state functional magnetic resonance imaging (fMRI).

Methods: The study included 9 patients with BEB (mean age, 61.7 years; range, 52–66 years), in whom the average duration of symptoms was 2.7 ± 1.8 years, and another 9 subjects from an age- and sex-matched control group. Resting state fMRI was performed in both the patients with BEB and the normal controls. Voxel-based analysis was used to characterize the alteration of amplitude of low-frequency fluctuation (ALFF) in both patients with BEB and the normal controls.

Results: The whole brain analysis indicated that in comparison with the normal control group, there was a significantly increased ALFF in the left putamen, pallidum, insular lobe, and medial prefrontal cortex and a significantly decreased ALFF in the bilateral somatosensory regions, thalami, cerebellum, and medial and posterior cingulate cortex.

Conclusion: The present study suggests that both an abnormal default mode network and corticostriatopallidothalamic loop may play a role in the pathophysiology of BEB.

Department of Neurology (BZ, JW, YH, YY), Sichuan Provincial People’s Hospital, Chengdu, China; and

Departments of Neurology (DZ)

Radiology (QG), West China Hospital, Sichuan University, Chengdu, China.

Address correspondence to Dong Zhou, Wai Nan Guo Xue Lane 37#, Chengdu, Sichuan 610041, China; E-mail: zhoudong6668@yahoo.cn

Supported by the National Natural Science Foundation of China (grant nos. 30625024 and 30728017), programs from the State Education Ministry (grant no. SRFDP-20060610073), the National Basic Research Program (973 Program No: 2007CB512305/2), and the National High Technology Program of China (863 program no: 2008AA02Z408).

The authors report no conflicts of interest.

© 2013 by North American Neuro-Ophthalmology Society