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Cancer-Associated Retinopathy in Neuroendocrine Carcinoma of the Fallopian Tube

Raghunath, Anitha MD; Adamus, Grazyna PhD; Bodurka, Diane C MD; Liu, Jinsong MD, PhD; Schiffman, Jade S MD

doi: 10.1097/WNO.0b013e3181e22ef0
Original Contributions

A 70-year-old woman developed progressive visual loss with compromised visual acuity and visual fields, cells in the anterior chamber and vitreous, attenuated retinal arterioles, and macular edema. She had undergone right oophorectomy and partial salpingectomy nearly 50 years earlier. Full-field and multifocal electroretinography showed waveforms of markedly attenuated amplitudes, findings consistent with cancer-associated retinopathy (CAR). Positron emission tomography revealed a nodule in the anterior wall of a right hydrosalpinx. Total laparoscopic hysterectomy yielded a neuroendocrine fallopian tube malignancy. She underwent partial treatment with paclitaxel and carboplatin that was aborted because of the development of herpes zoster infection. At 15 months following diagnosis, her ophthalmic status was stable. This is the first report of CAR in neuroendocrine carcinoma of the fallopian tube.

Departments of Ophthalmology (AR, JSS), Gynecologic Oncology (DCB), and Pathology (JL), The University of Texas M. D. Anderson Cancer Center, Houston, Texas; Department of Ophthalmology and Visual Sciences (AR), University of Texas Medical Branch, Galveston, Texas; and Ocular Immunology Laboratory, Department of Ophthalmology (GA), Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.

Address correspondence to Jade S. Schiffman, MD, Department of Ophthalmology, Unit 1445, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030; E-mail: jschiffm@mdanderson.org.

© 2010 Lippincott Williams & Wilkins, Inc.