Journal of Neuro-Ophthalmology

Skip Navigation LinksHome > June 2010 - Volume 30 - Issue 2 > Pegylated Interferon Alpha-Associated Optic Neuropathy
Journal of Neuro-Ophthalmology:
doi: 10.1097/WNO.0b013e3181d8e4af
Original Contributions

Pegylated Interferon Alpha-Associated Optic Neuropathy

Berg, Kathleen T BS; Nelson, Bruce MD; Harrison, Andrew R MD; McLoon, Linda K PhD; Lee, Michael S MD

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A 52-year-old man with chronic hepatitis C presented with painless, bilateral, simultaneous nonarteritic anterior ischemic optic neuropathy (NAION) and peripheral neuropathy. Symptoms began 19 weeks after starting peginterferon alpha-2a. The peripheral neuropathy and vision of the right eye improved, but the vision of the left eye worsened after stopping interferon. We identified 23 additional cases of NAION during interferon alpha therapy. At least 12 of these patients suffered bilateral NAION. Patients lost vision 1-40 weeks after initiating therapy. Of 21 eyes that had documented initial and follow-up acuities, 8 improved, 1 worsened, and the rest remained stable. One patient had a painful peripheral neuropathy. Treatment with interferon alpha may result in NAION. Discontinuation of therapy deserves consideration after weighing individual risks and benefits.

© 2010 Lippincott Williams & Wilkins, Inc.


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