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Clinical Without Histopathological Manifestations of Inflammation in a Patient With Primary Intraorbital Optic Nerve Sheath Meningioma

Lessell, Simmons MD; Kim, Jonathan W MD; Hatton, Mark P MD; Stemmer-Rachamimov, Anat MD; Thiagalingham, Sureka MBChB, MPH; Rubin, Peter A. D MD

Journal of Neuro-Ophthalmology: June 2007 - Volume 27 - Issue 2 - pp 104-106
doi: 10.1097/WNO.0b013e318064e495
Original Contribution

Abstract: A 28-year-old man with a biopsy-proven benign intraorbital optic nerve sheath meningioma developed recurrent clinical manifestations of ipsilateral retrobulbar inflammation 9 years after undergoing postoperative radiation therapy. Debulking of the tumor 11 years after the original surgery again revealed no pathologic signs of inflammation. Whether growth of tumor, surgery, radiation, or edema triggered the inflammatory manifestations is unclear. Our case affirms that primary optic nerve meningiomas may rarely cause episodic manifestations resembling those of idiopathic orbital inflammation that resolve with corticosteroid treatment.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, and the Department of Neuropathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Address correspondence to Simmons Lessell, MD, 243 Charles Street, Boston MA 02114; E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.