Anterior Ischemic Optic Neuropathy and Activated Protein C Resistance: A Case Report and Review of the Literature.Worrall, Bradford B. M.D.; Moazami, Golnaz M.D.; Odel, Jeffery G. M. D.; Behrens, Myles M. M.D.Journal of Neuro-Ophthalmology: September 1997 Original Articles: PDF Only Abstract Nonarteritic anterior ischemic optic neuropathy (AION) is a well-described entity that is believed to be caused by abnormal anatomy of the optic disc and to be precipitated by several stressor-s or disease states. Activated protein C resistance (APCR) is a recently described mutation of factor V (FV) gene that renders FV resistant to cleavage by activated protein C. APCR predisposes to thrombotic events. The case of a 61-year-old woman with AION and activated protein C resistance is presented, and the management is discussed. We thoroughly review the literature on these two conditions. We propose that a prospective analysis of the potential role of APCR in some cases of AION is needed and suggest that physicians consider this and other prothombotic states when evaluating patients with AION. (C) Williams & Wilkins 1997. All Rights Reserved.