This study tested a theoretical model derived from Kanter's theory of workplace empowerment by surveying a random sample of 300 registered nurses employed in acute care hospitals across the Canadian province of Ontario. The results of this study effectively replicated the findings of a previous exploratory study. Specific nursing practice environment characteristics that positively influence the climate of patient safety were identified. This study provides nurse leaders with ideas for improving the patient safety climate by improving the quality of nurses' work environments.