This prospective study examined whether the integration of acute care nurse practitioners (ACNP) in a semiclosed surgical intensive care unit (SICU) model increased compliance with clinical practice guidelines (CPG). Patients were admitted to critical care services with a (a) semiclosed/ACNP team or (b) mandatory consultation/non-ACNP team. CPG compliance was significantly higher (P < .05) on the semiclosed/ACNP team for all 3 CPGs examined in the study.