This article describes a hospital unit's successful central line-associated bloodstream infection reduction project. The focus is on decreasing and sustaining a low rate of infection by targeting improvement in central line maintenance. The Consolidated Framework for Implementation Research's 5 interacting domains (the intervention, inner and outer settings, individuals involved, and process) were used to guide the selection of 4 Plan-Do-Study-Act interventions. The rate decreased the rate from 3.2 to 0.6 infections per 1000 catheter-days.
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