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Glomus Tumor Presenting as a Periurethral Mass

Malowany, Janet I. BHSc1; Rieckenberg, R. Mark MD, FRCPC2; Okafo, Benjamin A. MD, FRCSC2; Colgan, Terence J. MD, FRCPC, FCAP, MIAC3

Journal of Lower Genital Tract Disease: October 2008 - Volume 12 - Issue 4 - pp 316-319
doi: 10.1097/LGT.0b013e31816a0db1
Case Report

Objectives. Glomus tumors, a neoplasm arising from the glomus body, usually occur in the extremities with a particular predisposition to a subungual site. Glomus tumors are exceedingly rare in the external genitalia. In this case, the origin of a periurethral mass proved to be a glomus tumor.

Materials and Methods. A 61-year-old woman presented with postmenopausal vaginal bleeding. Clinical examination revealed a focally ulcerating, soft periurethral mass. A subsequent wedge biopsy of a periurethral, submucosal tumor was examined microscopically using both hematoxylin and eosin stains and an extensive immunohistochemical panel.

Results. The initial histopathologic differential diagnosis of the wedge biopsy included several neoplasms, but final analysis, including immunohistochemistry (vimentin, desmin, and calponin positivity), concluded that the lesion was a glomus tumor.

Conclusions. Periurethral masses are rare and may be caused by a large number of neoplastic and nonneoplastic lesions. This case of glomus tumor presenting as a periurethral mass may be the only third reported occurrence.

Glomus tumor may be a rare cause of a submucosal periurethral mass.

1Schulich School of Medicine & Dentistry, University of Western Ontario, London, 2Orillia Soldiers Memorial Hospital, Orillia, and 3Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada

Correspondence to: Terence J. Colgan, MD, FRCPC, FCAP, MIAC, Sections of Gynaecological Pathology, & Cytopathology, Pathology & Laboratory Medicine, Mount Sinai Hospital, Room 6-502-3, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5. E-mail: tcolgan@mtsinai.on.ca

©2008The American Society for Colposcopy and Cervical Pathology