Skip Navigation LinksHome > July 2015 - Volume 19 - Issue 3 > Microbiological Infections in Women With Cervical Cytologica...
Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0000000000000078
Original Articles - Cervix and HPV

Microbiological Infections in Women With Cervical Cytological Reports of Atypical Squamous Cells of Undetermined Significance

Paba, Pierpaolo PhD1; Criscuolo, Anna Angela MD2; Grazia Giancipoli, Romina MD2; Santi, Flavia MSc3; Ascone, Chiara MD2; Sesti, Francesco MD2; Piccione, Emilio MD2; Perno, Carlo Federico MD1,4; Favalli, Cartesio MD4,5; Ciotti, Marco MD1

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Objective: To study the role of cervicovaginal infections in women with cytological reports of atypical squamous cells of undetermined significance (ASC-US).

Materials and Methods: The study included 220 women admitted to the Clinic of Microscopy, Cervicovaginal and Vulvar Pathology of the Department of Gynecology and Obstetrics of the Tor Vergata University Hospital, Rome, Italy, enrolled between October 2012 and July 2013.

Results: Among the enrolled women, 105 women (47.7%) had ASC-US cytology, whereas 115 women (52.3%) had negative cytology. Microscopy showed infections more frequently in women with ASC-US than in those with negative cytology: 70.5% (74/105) vs 36% (41/115); p < .001. Cocci were present in 73.3% (77/105) of the women with ASC-US and in 43.5% (50/115) of those with negative cytology; p < .001. According to Ison score, 84% (88/105) of ASC-US was grade 0 vs 22% (25/115) of negative cytology, p < .001. Human papillomavirus was detected in 35% of the women with ASC-US. A statistically significant correlation between high pH and vaginal infections was found in women aged 20 to 29 (p = .003) and those 50 years or older in both cytological report groups; p < .001.

Conclusions: Cervicovaginal infections are associated with a cytological report of ASC-US. Direct microscopy of vaginal specimens allowing immediate evaluation of the vaginal microflora and infectious agents may be a useful tool in managing women with cytological reports of ASC-US.

Copyright © 2015 by the American Society for Colposcopy and Cervical Pathology


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