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Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0000000000000019
Original Article: PDF Only

Do Colposcopically Directed Biopsy and Endocervical Curettage Serve to Induce Regression of Cervical Intraepithelial Neoplasia?.

Diedrich, Justin T. MD; Felix, Juan C. MD; Lonky, Neal M. MD, MPH

Published Ahead-of-Print
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Abstract

Objective: We investigated the clinical and demographic characteristics that could influence regression of cervical intraepithelial neoplasia (CIN) from colposcopy to excision, and evaluated the association of the performance of multiple biopsies and endocervical curettage (ECC) with regression of high-grade (CIN 2+) by the time of excisional therapy.

Materials and Methods: This was an institutional review board-approved retrospective analysis of 555 patients who had abnormal screening and who underwent colposcopy followed by cervical excision procedures for CIN 2+ or high-risk status. We assessed demographic variables, referral reason, colposcopic findings, and the latency between colposcopic biopsy and excision to which we correlated the likelihood of regression of disease on the excisional specimen.

Results: Mean age was 39 years, and median interval from colposcopy to excision was 48 days. Neither demographics nor colposcopic findings influenced the probability of regression. Patients with shorter intervals between colposcopy biopsy and excision exhibited a higher rate of regression (p = .04). The addition of ECC to colposcopy was associated with regression (p = .002).

Conclusions: During routine colposcopic practice using punch biopsy and ECC when indicated, regression was less likely with longer latency from colposcopy to excision. This was possibly owing to emergence and documentation of persistent occult neoplasia. The effect of intentional complete biopsy excision with conventional tools as a potential therapeutic intervention was not evaluated.

Copyright (C) 2014 by the American Society for Colposcopy and Cervical Pathology

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