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Clinicopathologic Study of Vulvar Pagets Disease in China

Liu, Guoyan MD, PhD; Yuan, Bibo MD, PhD; Wang, Yingmei MD, PhD; Xue, Fengxia MD, PhD

Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e3182a64a58

Objective: To assess the clinicopathologic characteristics of patients with vulvar Paget’s disease who were admitted in our hospital or of cases reported in a Chinese journal.

Methods: The age, disease course, clinical manifestation, pathologic diagnosis, treatment, and follow-up data of patients with vulvar Paget’s disease were reviewed.

Results: There were 85 cases of vulvar Paget’s disease reviewed. The mean age of patients with vulvar Paget’s disease was 64.4 years, and their mean disease course was 52.36 months. The patients’ primary clinical manifestations were pruritus. Treatment included simple vulvectomy, wide local excision, partial vulvectomy, radical vulvectomy with/without groin dissection, and radiotherapy. Intraepithelial Paget’s disease was the most common pathology type (61.5%) followed by invasive Paget’s disease (20.0%). There were 7 patients who had a history of secondary malignancy. The mean follow-up period was 43.6 months. The recurrence rate was as high as 43.5%. No significant relationships between margin status, lymph node involvement, pathology type, and recurrence were found (p > .05).

Conclusions: Vulvar Paget’s disease has a high local recurrence risk and a long-term follow-up is required.

Author Information

Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, China

Reprint requests to: Fengxia Xue, MD, PhD, Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, No. 154 Anshan St, Heping District, Tianjin, PR China 300052. E-mail:

The authors have declared they have no conflicts of interest.

Dr Liu is a New-Century Outstanding Fellow of Tianjin Medical University General Hospital and was supported by National Nature Science Foundation of China (grant no. 81101673).

Copyright © 2014 by the American Society for Colposcopy and Cervical Pathology