Skip Navigation LinksHome > April 2014 - Volume 18 - Issue 2 > Carcinoma of the Neovagina After Male-to-Female Reassignment
Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e3182976219
Case Reports

Carcinoma of the Neovagina After Male-to-Female Reassignment

Fernandes, Hugo M. MBBS, FRANZCOG; Manolitsas, Tom P. MBBS, MRCOG, FRANZCOG, CGO, MD; Jobling, Tom W. MBBS, FRCOG, FRANZCOG, CGO, MD

Collapse Box


Background: Carcinoma of the neovagina is extremely rare, and only one other case has been reported after sex-reassignment surgery. Malignancies seem to be dependent on the original tissue and are thought to be associated with HPV infection or chronic irritation.

Case Report: A 53-year-old male-to-female transsexual presented 21 years after initial surgery with vaginal discharge that was found to be due to a moderately differentiated squamous cell carcinoma. She was treated with chemoradiation with disease remission; however, she had significant stenosis and narrowing of the neovagina.

Comment: The optimum treatment is unclear, although radiation seems to be the most common technique with surgery an alternative. All patients should have regular clinical follow-up provided by a primary treating unit, which includes pelvic examination and cytologic smears. As a minimum, follow-up should occur as per other vaginal malignancies for at least 10 years.

Copyright © 2014 by the American Society for Colposcopy and Cervical Pathology


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.