Skip Navigation LinksHome > April 2013 - Volume 17 - Issue 2 > Cervical Epithelial Brightness by Optical Coherence Tomograp...
Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e31825d7bf0
Original Articles

Cervical Epithelial Brightness by Optical Coherence Tomography Can Determine Histological Grades of Cervical Neoplasia

Belinson, Suzanne E. PhD1; Ledford, Katy BA2; Rasool, Nabila MD3; Rollins, Andrew PhD4; Wilan, Na MD5; Wang, Chun MD5; Rong, Xuan MD5; Zhang, Wei MD5; Zhu, Yasha MD5; Tresser, Nancy PhD6; Wu, RuiFang MD5; Belinson, Jerome L. MD1,3

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Objective: The study aimed to determine if the difference in cervical epithelium brightness, as measured by optical coherence tomography (OCT), has potential as a distinguishing characteristic of normal, low-grade, high-grade (cervical intraepithelial neoplasia 2+), and cancer histological findings.

Materials and Methods: Information from 476 women was available for analysis. Demographic information was collected through in-person interview. All participants were human papillomavirus positive and/or had abnormal cytological finding and underwent colposcopy or unaided visual inspection and examination by OCT by quadrant. All women had a minimum of 4 OCT-matched cervical biopsies and endocervical curettage. Two sample t tests were used to measure differences in OCT image brightness by histological grades.

Results: Mean OCT image brightness differed significantly between each preinvasive histological grade and invasive cancer (p < .01 for all comparisons). Brightness as measured by OCT was also able to differentiate between squamous metaplasia and cervical intraepithelial neoplasia 3/cancer; p values were .004 and .003, respectively.

Conclusions: Epithelial brightness is an important component of cervical epithelium diagnosis by OCT, and we plan to add it to our diagnostic mathematical algorithm in all future versions of OCT software.

©2013The American Society for Colposcopy and Cervical Pathology


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