Objective: The study aimed to report 2 cases of desquamative inflammatory vaginitis associated with toxic shock syndrome toxin 1 (TSST-1)–producing Staphylococcus aureus strains.
Materials and Methods: Case report of 2 patients, 1 with an acute and 1 with a chronic presentation, diagnosed with desquamative inflammatory vaginitis on the basis of clinical findings and wet mount microscopy. Pretreatment and posttreatment vaginal bacterial and yeast cultures were obtained.
Results: Pretreatment vaginal bacterial cultures from both patients grew TSST-1–producing S. aureus. Subsequent vaginal bacterial culture results after oral antibiotic therapy were negative.
Conclusions: Desquamative inflammatory vaginitis may be triggered through TSST-1–mediated vaginal toxic shock reaction.
Desquamative inflammatory vaginitis may be triggered through toxic shock syndrome toxin 1&#x2013;mediated vaginal toxic shock reaction.
Departments of 1Obstetrics and Gynecology and 2Microbiology and Immunology, College of Medicine, Drexel University, Philadelphia, PA; and 3Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA
Reprint requests to: Nigel Pereira, MD, Department of Obstetrics and Gynecology, Drexel University College of Medicine, 245 N. 15th St, MS 495, 16th Floor, New College Bldg, Philadelphia, PA 19102. E-mail: Nigel.Pereira@drexelmed.edu
Patrick M. Schlievert was funded by USPHS research grants AI-74283 and AI57153 from the NIH-supported Great Lakes Regional Center for Excellence in Biodefense and Emerging Diseases of which he is a member. For the remaining authors, none were declared.