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Obstetric Outcomes After Treatment for Cervical Intraepithelial Neoplasia: Six Years of Experience

Lima, Ana Furtado MD; Francisco, Carla MD; Júlio, Catarina MD; Paula, Tereza MD; Vitorino, Adelaide MD; Borrego, Jorge MD

Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e31821a6823
Original Articles

Objective: The purpose of this study was to assess the effect of cervical conization on subsequent pregnancy and delivery outcomes.

Materials and Methods: A retrospective case-control study was performed in patients who underwent conization from 2000 to 2005 and had a subsequent delivery. Two case controls were matched for each case studied. The obstetric outcomes of the 2 groups were compared. A subsequent analysis comparing the 2 excisional techniques used was performed.

Results: The study population group included 87 women (29 cases and 58 controls). Overall, the mean gestation age at delivery (38 vs 39 wk, p = .003), prevalence of preterm birth (20.7% vs 5.2%, p = .025), mean birth weight (3,035 vs 3279 g, p = .018), and low birth weight (20.7% vs 1.7%, p = .02) were statistically different among the cases and controls.

In the study group (n = 29), large loop excision of the transformation zone was used in 62% (n = 18) and laser was used in 38% (n = 11) of the cases. There was no significant difference in the medium depth of the excised tissue, the prevalence of preterm birth, low birth weight, and the cesarean delivery rate between the 2 techniques.

Conclusions: Despite the small number of cases, this study indicates that excision of the transformation zone is associated with an increased risk of overall preterm delivery and low-birth weight infants in subsequent pregnancies. No significant difference was found between the 2 cervical excision procedures.

In Brief

Cervical excision procedures increase risk of preterm delivery and low-birth weight infants in subsequent pregnancies, but there is no difference between LLETZ and laser cone.

Author Information

Colposcopy Unit, Gynecology Department, Dr Alfredo da Costa Maternity, Lisbon, Portugal

Reprint requests to: Ana Furtado Lima, MD, Avenida Columbano Bordalo Pinheiro, N° 88, 1° E, 1070-065, Lisbon, Portugal. E-mail:

©2011The American Society for Colposcopy and Cervical Pathology