Skip Navigation LinksHome > October 2011 - Volume 15 - Issue 4 > Dermasilk Briefs in Vulvar Lichen Sclerosus: An Adjuvant Too...
Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e31821380a0
Original Articles

Dermasilk Briefs in Vulvar Lichen Sclerosus: An Adjuvant Tool

D'Antuono, Antonietta MD1; Bellavista, Sara MD1; Negosanti, Francesca MD1; Zauli, Stefania MD1; Baldi, Elena MD2; Patrizi, Annalisa MD1

Collapse Box


Objective: The purpose of our study was to evaluate whether briefs made of Dermasilk fabric could be an adjuvant tool in the management of vulvar lichen sclerosus (LS).

Materials and Methods: A controlled, randomized, double-blind study versus placebo was conducted, comparing Dermasilk versus standard cotton briefs in patients affected by LS during treatment with clobetasol propionate 0.05% ointment and vitamin E moisturizer. For each patient, an evaluation of objective genital signs and subjective symptoms typical of LS was recorded before the start of treatment, after 1 month, and after 6 months of the study. Statistical analysis was performed with SPSS 17.0 for Windows.

Results: Forty-two women affected by LS were recruited and divided into those wearing Dermasilk or cotton briefs. Patients wearing Dermasilk briefs showed a better improvement in the clinical symptoms of burning sensation, skin irritation, and pain (Fisher test, p < .0001) compared with the cotton placebo group. The improvement in itching was also faster in the Dermasilk group (Fisher exact test, p < .05). Erythema also showed a better improvement in the Dermasilk group (Fisher test, p < 0.05).

Conclusions: Dermasilk fabric seems to be a useful adjunct to topical treatment in producing a better and more rapid control of symptoms in patients with LS.

©2011The American Society for Colposcopy and Cervical Pathology


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.