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Dermasilk Briefs in Vulvar Lichen Sclerosus: An Adjuvant Tool

D'Antuono, Antonietta MD1; Bellavista, Sara MD1; Negosanti, Francesca MD1; Zauli, Stefania MD1; Baldi, Elena MD2; Patrizi, Annalisa MD1

Journal of Lower Genital Tract Disease: October 2011 - Volume 15 - Issue 4 - pp 287-291
doi: 10.1097/LGT.0b013e31821380a0
Original Articles

Objective: The purpose of our study was to evaluate whether briefs made of Dermasilk fabric could be an adjuvant tool in the management of vulvar lichen sclerosus (LS).

Materials and Methods: A controlled, randomized, double-blind study versus placebo was conducted, comparing Dermasilk versus standard cotton briefs in patients affected by LS during treatment with clobetasol propionate 0.05% ointment and vitamin E moisturizer. For each patient, an evaluation of objective genital signs and subjective symptoms typical of LS was recorded before the start of treatment, after 1 month, and after 6 months of the study. Statistical analysis was performed with SPSS 17.0 for Windows.

Results: Forty-two women affected by LS were recruited and divided into those wearing Dermasilk or cotton briefs. Patients wearing Dermasilk briefs showed a better improvement in the clinical symptoms of burning sensation, skin irritation, and pain (Fisher test, p < .0001) compared with the cotton placebo group. The improvement in itching was also faster in the Dermasilk group (Fisher exact test, p < .05). Erythema also showed a better improvement in the Dermasilk group (Fisher test, p < 0.05).

Conclusions: Dermasilk fabric seems to be a useful adjunct to topical treatment in producing a better and more rapid control of symptoms in patients with LS.

1Department of Internal Medicine, Geriatry and Nephrology, Section of Dermatology, San'Orsola-Malpighi Hospital, University of Bologna; and 2Department of Medicine and Public Health, University of Bologna, Bologna, Italy

Correspondence to: Sara Bellavista, MD, Section of Dermatology, University of Bologna, Via Massarenti 1, 40139 Bologna, Italy. E-mail: sara.bellavista4@unibo.it

Alpretec, producer of Dermasilk briefs, provided materials required to perform the study.

©2011The American Society for Colposcopy and Cervical Pathology